Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Moeller BJ(1), Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY, Dewhirst MW. Author information: (1)Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.

av AC Karlsson · 2014 — The results from this thesis suggest that a mutation in the PMEL17 and TSHR genes have pleiotropic effects on behaviour and traits related to 

2013 — In the simplest terms pleiotropy means genetic side-effects: a pleiotropic gene is a gene that does several things and a pleiotropic variant is a  Testosterone causes pleiotropic effects on cleanerfish behaviour. MC Soares, R Mazzei, SC Cardoso, C Ramos, R Bshary. Scientific reports 9 (1), 1-10, 2019. Research has indicated that statins also possess some pleiotropic effects that are independent of the cholesterol lowering properties. It is thought that the  studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects.

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An antagonistically pleiotropic gene can be selected for if it has beneficial effects in early life while having its negative effects in later life because genes tend to have larger impacts on fitness in an organism's prime than in their old age. An example of this is testosterone levels in male humans. Recent experimental evidence supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability). Pleiotropic effects of IL-8 on leukocytes have also been delineated in part by the use of antisense approaches.

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Regulatory agencies require that new cholesterol-lowering treatments should be tested on top of background standard of care therapy, including statins. The most important positive effects of statins are anti-inflammatory, anti-proliferative, antioxidant, immunomodulatory, neuroprotective, anti-diabetes, and antithrombotic, improving endothelial dysfunction and attenuating vascular remodeling besides many others which are discussed under the scope of this review. The rationale is that because many genes now appear to have pleiotropic effects, the drugs that interact with the products of these genes could have uses in multiple body systems. A pharmaceutical company called Pharnext has developed a treatment for a rare, incurable neurodegenerative condition called Charcot-Marie-Tooth disease, which is caused by a single-gene duplication.

The pleiotropic effects of vitamin D and associated mechanisms are summarized in Table 1. In addition, the paracrine and autocrine effects of vitamin D have a protective role in many diseases. Therefore, the application of vitamin D in disease treatment and prevention should be pursued. Pleiotropic effects…

Artikel i  Additional adverse effects, for example, pleiotropic effects, might have been generated as a result of the method used to create the transgenes, and of the  With summer right around the corner, huge kiosks of sunscreen are on display at stores everywhere, reminding us to fear the sun. We've been told for years that  1 jan. 2021 — including immunomodulatory activity, protection against respiratory tract infections and pleiotropic effects on the cardiovascular system. Pleiotropic effects accompanying atrazine resistance were investigated in atrazine-resistant (AR) and susceptible (S) biotypes of horseweed (Conyza  No pleiotropic effects on stem height or diameter growth were observed. The results establish a central role for the FRK2 activity in carbon flux to wood cellulose.

The rationale is that because many genes now appear to have pleiotropic effects, the drugs that interact with the products of these genes could have uses in multiple body systems. A pharmaceutical company called Pharnext has developed a treatment for a rare, incurable neurodegenerative condition called Charcot-Marie-Tooth disease, which is caused by a single-gene duplication. pleiotropy. the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen.
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Direct additive genetic effects are the result of a single causal variant related to multiple traits, independently of its individual effects on each of them and the dependency or causal relationship between different phenotypes.

compare the effects of statins and fibrates on laboratory parameters in Japanese patients in routine clinical practice. This retrospective cohort study included patients with dyslipidemia who had been newly treated with statin or fibrate monotherapy between January 2005 and December 2017. Patients were randomly matched into two sets of pairs by sex, age, and baseline triglyceride (TG) or low The pleiotropic effect is produced by a gene owing to a cascade (succession) of reactions during some metabolic pathway which is influenced by the original gene product and contributes to different phenotypic effects. The ratio is 2:1 instead of 3:1.
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Nov 19, 2018 Statins exerts their pleiotropic effects by hindering the conversion of HMG-CoA to L-mevalonic corrosive, statins keep the union of imperative 

2019 — Orion has studied the effects of oral levosimendan on respiratory ALS, a number of other pleiotropic effects of the drug raise some intriguing  The effect of a fibre supplement compared to a healthy diet on body composition, lipids, Pleiotropic effects of ezetimibe/simvastatin vs. high dose simvastatin.

Jul 8, 2020 The gene having a multiple phenotypic effect because of its ability to control expression of two or more characters is called pleiotropic gene.

pleiotropy. the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen. Definition of pleiotropic. : producing more than one effect especially : having multiple phenotypic expressions a pleiotropic gene.

Circ Res. SS, Blumenthal RS. Non-cardiovascular effects associated with statins. 10 nov. 2017 — Lipids Health Dis. 15, 118 (2016).